Open AccessAnaphylaxis to gadobutrol and gadoterate meglumine in a patient with low grade astrocytoma
Author(s) -
Montalvo Juan Manuel Escobar,
Ballesteros Ruth Mielgo,
Jimenez Ruth Barranco
Publication year - 2014
Publication title -
clinical and translational allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.979
H-Index - 37
ISSN - 2045-7022
DOI - 10.1186/2045-7022-4-s3-p6
Subject(s) - medicine , anaphylaxis , gadobutrol , iodinated contrast , premedication , histamine , anesthesia , gadolinium , magnetic resonance imaging , allergy , radiology , computed tomography , immunology , materials science , metallurgy
Method A 58-year old woman with low grade astrocytoma, who had previously tolerated Gadolinium-based contrasts, was diagnosed with anaphylaxis to Gadobutrol by history of anaphylaxis after intravenous administration and positive skin testing. For these reasons Gadobutrol administration was banned and was given a premedication protocol (steroids and antihistamines) if the patient will require future administrations of other Gadolinium-based agents. However, one year later, despite premedication the patient presented with pruritus and hives disseminated, breathlessness, dizziness and hypotension two minutes after administration of Gadoterate Meglumine in a control brain MRI. Skin testing with Gadoterate meglumine, and Gadopentetic acid was carried out. Histamine and isotonic saline were used as positive and negative controls respectively.