Open AccessAnalysis of B cell subsets in severe cutaneous adverse reaction
Author(s) -
Azukizawa Hiroaki,
Kato Kenichi,
Katayama Ichiro
Publication year - 2014
Publication title -
clinical and translational allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.979
H-Index - 37
ISSN - 2045-7022
DOI - 10.1186/2045-7022-4-s3-p44
Subject(s) - regulatory b cells , medicine , cd19 , toxic epidermal necrolysis , immunology , b cell , peripheral blood mononuclear cell , antibody , biology , dermatology , in vitro , biochemistry
T cells play an important role in the pathogenesis of severe cutaneous adverse reaction (SCAR), while the role of B cell immunity in SCAR is unclear. It has been reported that number of B cell and serum IgG are decreased in the patient’s peripheral blood of drug-induced hypersensitivity syndrome (DIHS) / drug reaction with eosinophilia and systemic symptoms (DRESS) in the acute stage. Regulatory B cell (Breg) is a IL-10 producing cell and negatively regulates cellular immunity in the mouse autoimmune disease model. Also in the mouse model, B-1 B cell secretes immunoglobulin against microbial infection in a T cellindependent manner. Recently, Breg and B-1 B cell were identified as minor populations of human B cells in the peripheral blood, however, the roles of these B cells in SCAR are unknown. Here, we studied the ratio of Breg and B-1 B cells in the peripheral blood B cells of SCAR patients.