Open AccessCharacterization of amoxicillin and clavulanic‐acid‐responsive CD4+ And CD8+ T‐cells in patients with co‐amoxiclav‐induced liver injury
Author(s) -
Kim SeungHyun,
Saide Katy,
Yuan Ye,
Daly Ann,
Alfirevic Ana,
Pirmohamed Munir,
Park Kevin,
Naisbitt Dean
Publication year - 2014
Publication title -
clinical and translational allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.979
H-Index - 37
ISSN - 2045-7022
DOI - 10.1186/2045-7022-4-s3-p42
Subject(s) - clavulanic acid , elispot , amoxicillin , liver injury , medicine , amoxicillin/clavulanic acid , cd8 , immune system , pharmacology , immunology , microbiology and biotechnology , antibiotics , biology
Background Co-amoxiclav, a combination antibiotic consisting of amoxicillin and clavulanic acid, is one of the most commonly prescribed anti-microbial drugs. Unfortunately, human exposure is associated with liver injury and in rare cases, acute liver failure has been reported. The risk of liver injury appears be higher when amoxicillin/clavulanic acid is used in combination. Little is known about the mechanistic basis of co-amoxiclav-induced liver injury. However, several HLA class I and II genotypes have recently been shown to affect susceptibility, which indicates a potential role for the adaptive immune system. Thus, the objective of this study was to (1) investigate whether drug responsive T-cells are detectable in the peripheral blood of patients with co-amoxiclav-induced liver injury, (2) define antigen specificity and (3) characterize the phenotype and function of antigen-specific T-cells.