Open AccessAn immunohistochemical study of the granulysin expression of 6 types of proven adverse cutaneous drug reaction
Author(s) -
Weinborn Marie,
Barbaud Annick,
Truchetet François,
Beurey Philippe,
Germain Lucie,
Schmutz JeanLuc,
Cribier Bernard
Publication year - 2014
Publication title -
clinical and translational allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.979
H-Index - 37
ISSN - 2045-7022
DOI - 10.1186/2045-7022-4-s3-p3
Subject(s) - granulysin , acute generalized exanthematous pustulosis , toxic epidermal necrolysis , medicine , drug eruption , drug reaction , drug , dermatology , adverse drug reaction , immunohistochemistry , pathology , immunology , pharmacology , immune system , perforin , cd8
Background In Steven Johnson’s syndrome (SJS) and Toxic epidermal necrolysis (TEN), Chung et al. demonstrated that granulysin is the key cytotoxic molecule. But the specificity of granulysin in SJS-TEN is actually discussed. We studied the granulysin expression of 6 types of cutaneous adverse drug reaction (CADR) with a proven diagnosis (maculopapular exanthema (MPE), Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS), fixed drug eruption (FDE), SJS, TEN, acute generalized exanthematous pustulosis (AGEP)).