Open AccessAspirin hypersensitivity in Iranian patients with chronic rhinosinusitis and nasal polyposis: prevalence and comorbid factors
Author(s) -
Esmaeilzadeh Hossein,
Nabavi Mohammad,
Arshi Saba,
Bemanian Mohammad Hassan,
Bahrami Ahmad,
Fallahpour Morteza,
Mortazavi Negar,
Rezaei Nima
Publication year - 2014
Publication title -
clinical and translational allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.979
H-Index - 37
ISSN - 2045-7022
DOI - 10.1186/2045-7022-4-s3-p22
Subject(s) - medicine , eosinophilia , nasal polyps , aspirin , asthma , eosinophil , atopy , allergy , provocation test , gastroenterology , patch test , immunology , pathology , alternative medicine
Background Aspirin (ASA) hypersensitivity is frequent in patients with chronic rhinosinusitis and nasal polyps (CRSwNP), which is called aspirin exacerbated respiratory disease (AERD). However, there are few studies on evaluating the prevalence of ASA hypersensitivity in patients with nasal polyps (NPs), using the oral aspirin challenge test. This study was designed to determine the frequency of ASA hypersensitivity and factors associated with ASA hypersensitivity in patients with CRSwNP. Methods Eighty Iranian patients (43 women and 37 men) with CRSwNP were enrolled in this study. Extension of NPs was evaluated by endoscopic examination. A single day, oral aspirin challenge (OAC) was used to detect ASA hypersensitivity. Atopic evaluation was performed, using skin prick test, nasal smear, blood eosinophil count, and serum total IgE. Results