Open AccessHumoral biomarkers of latex allergy
Author(s) -
GiavinaBianchi Pedro,
Garro Laila Sabino,
Aun Marcelo Vivolo,
Motta Antonio Abílio,
Castells Mariana,
Kalil Jorge
Publication year - 2014
Publication title -
clinical and translational allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.979
H-Index - 37
ISSN - 2045-7022
DOI - 10.1186/2045-7022-4-s3-p128
Subject(s) - latex allergy , medicine , allergy , immunoglobulin e , sensitization , asymptomatic , immunology , anaphylaxis , dermatology , antibody
Results The prevalence of sensitization and allergy to latex in patients presenting defects in neural tube closure was 33.2% and 12.2%, respectively. Cutaneous manifestations of latex allergy were the most common (79.6%), but anaphylaxis was observed in 4.75% of patients. Clinical and surgical factors associated with latex allergy were identified and a symptom score to screening patients was developed. Concentration of specific IgE to latex >0.77 kUA/l presented good accuracy in differentiating asymptomatic sensitization from allergy. Measurement of specific IgE to recombinant allergens also showed good accuracy in the diagnosis of allergy. The specific serum IgG4 concentration was negatively associated with allergy to latex, but this was not observed for specific IgA. Conclusion Higher concentration of specific IgE to latex and Hevb5, lower concentration of specific IgG4 to latex and symptom score iÝ 40% were associated with latex allergy.