Open AccessHLA‐B*15:02 genotype associated with hypersensitivity syndrome to lamotrigine in Thai population
Author(s) -
Koomdee Napatrupron,
Jantararoungtong Thawinee,
Rerkpattanapipat Ticha,
Prommas Santirat,
Santon Siwalee,
Chammanphol Montri,
Puangpetch Apichaya,
Sukasem Chonlaphat
Publication year - 2014
Publication title -
clinical and translational allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.979
H-Index - 37
ISSN - 2045-7022
DOI - 10.1186/2045-7022-4-s3-p121
Subject(s) - lamotrigine , toxic epidermal necrolysis , medicine , allele , epilepsy , population , immunology , dermatology , psychiatry , genetics , biology , gene , environmental health
Method A total of 133 patients, including 11 patients with lamotrigine-induced hypersensitivity syndrome (MPE; maculo-papular exanthema, SJS; Stevens-Johnson syndrome and TEN; toxic epidermal necrolysis), 9 lamotrigine-tolerant controls and 113 healthy controls were included in this study. HLA-B genotyping was performed. This case-control study was approved by the Ethics Committee of Ramathibodi Hospital.