Open AccessHistopathology of the exanthema in DRESS in correlation with markers of severe systemic involvement
Author(s) -
Gonçalo Margarida,
Coutinho Inês,
Gouveia Miguel,
Cabral Rita,
Pereira Neide,
Cardoso José Carlos,
Tellechea Óscar
Publication year - 2014
Publication title -
clinical and translational allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.979
H-Index - 37
ISSN - 2045-7022
DOI - 10.1186/2045-7022-4-s3-o8
Subject(s) - medicine , spongiosis , histopathology , pathology , atypical lymphocyte , skin biopsy , neutrophilia , toxic epidermal necrolysis , eosinophil , parakeratosis , erythema , dermatology , dermatopathology , eosinophilia , lymphocyte , biopsy , immunology , lymphoma , asthma
Methods Skin biopsies performed in in-patients with a diagnosis of DRESS according to REGISCAR criteria, were independently evaluated by two Dermatopathologists. Epidermal and dermal parameters were scored (lymphocyte, eosinophil and neutrophil infiltrate, lymphocyte exocytosis, spongiosis and necrotic/vacuolated keratinocytes) and correlated with the severity of systemic symptoms (eosinophilia, liver cytolysis and cholestasis, evaluated respectively by serum ALT and GGT values) and the presence of circulating HHV-6 DNA.