Open AccessDiagnostic usefulness of histamine release test (HRT) and skin tests in IgE‐mediated allergy to clavulanic acid
Author(s) -
Pineda Fernando,
Ariza Adriana,
Mayorga Cristobalina,
Perez Inmaculada,
GonzalezMendiola Rosario,
Blanca Natalia,
Davila Galicia,
Cabañes Nieves,
Canto Gabriela,
Laguna Jose Julio,
Senent Carlos,
Skov Per Stahl,
Palacios Ricardo,
Blanca Miguel
Publication year - 2014
Publication title -
clinical and translational allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.979
H-Index - 37
ISSN - 2045-7022
DOI - 10.1186/2045-7022-4-s3-o7
Subject(s) - medicine , provocation test , sensitization , allergy , drug allergy , gastroenterology , angioedema , immunoglobulin e , amoxicillin , anaphylaxis , context (archaeology) , clavulanic acid , immunology , histamine , antibiotics , dermatology , pathology , antibody , microbiology and biotechnology , paleontology , biology , alternative medicine
Methods Nineteen patients with an immediate hypersensitivity reaction after AX-CLV administration were evaluated. Skin tests were done with PPL, DM, AX and CLV (DIATER, Madrid, Spain). Controls (n=21) with proven AX-CLV tolerance were included in the context of a Spanish cross-sectional multicentric study including five hospitals. In vitro tests were performed by direct and passive sensitization HRT (Reflab, Copenhagen, Denmark) using AX and CLV at different concentrations. Tolerance to AX was assessed by DPT.