Open AccessCutaneous adverse drug reactions induced by Oxcarbazepine
Author(s) -
Hsiao YiHsin,
Chung WenHung
Publication year - 2014
Publication title -
clinical and translational allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.979
H-Index - 37
ISSN - 2045-7022
DOI - 10.1186/2045-7022-4-s3-o12
Subject(s) - oxcarbazepine , medicine , carbamazepine , toxic epidermal necrolysis , dermatology , drug , drug reaction , pharmacology , gastroenterology , epilepsy , psychiatry
Poster background Oxcarbazepine (OXC) is a structural analog of carbamazepine (CBZ). OXC is considered a promising alternative medication for patients who cannot tolerate CBZ because of its equivalent clinical effiecacy and fewer cutaneous adverse drug reactions (cADRs) compared to CBZ. HLAB*15:02 allele was shown to strongly associate with carbamazepine (CBZ)-induced Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) in Chinese and Southeast Asian populations.However,the epidemiological data about OXC-induced cADRs in recent years is limited. This study aims to investigate the clinical characteristics of OXC-induced cADRs and their genetic associations with HLA-B*15:02.