Open AccessSequential allergen microarray testing during the follow‐up of allergic patients
Author(s) -
Vitte Joana,
Agabriel Chantal,
Liabeuf Valérie,
Cleach Isabelle,
Grob JeanJacques,
Sarles JeanJacques,
Bongrand Pierre
Publication year - 2014
Publication title -
clinical and translational allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.979
H-Index - 37
ISSN - 2045-7022
DOI - 10.1186/2045-7022-4-s2-p48
Subject(s) - medicine , allergen , allergy , thaumatin , immunoglobulin e , immunology , bioinformatics , biology , antibody , genetics , gene
Results Median age was 6 years (10 months to 17 years) when ISAC was first performed, and 8 years (22 months to 18 years) when the latest ISAC was performed. With respect to the number and intensity of IgE reactivities, ISAC follow-up results entered one of the following categories: progression (16), stability (12), attenuation (8). Two patients displayed complex alterations of their molecular profile over time. In most cases, ISAC followup provided aid for the management of food exclusion or reintroduction regimens. Storage protein reactivity was the most frequent setting, but transition from one molecular profile to another, which were not clinically distinguishable, such as lipid tranfer proteins versus thaumatin-like proteins, was als noted. Complex cross-reactivity patterns or allergy to components which are unavailable for individual testing (sesame Ses i 1, thaumatin-like Act d 2, 7S vicillins other than those from Fabaceae, wheat Tri a 14) gained better insight from repeated ISAC assays. Finally, sequential “allergen landscape views” improved the understanding of the patient’s biological and clinical evolution.