Open AccessExperimentally‐induced early recruitment of CD14+ monocytes in human allergic rhinitis
Author(s) -
EguiluzGracia Ibon,
Melum Guro R,
Baekkevold Epsen S,
Jahnsen Frode L
Publication year - 2014
Publication title -
clinical and translational allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.979
H-Index - 37
ISSN - 2045-7022
DOI - 10.1186/2045-7022-4-s2-o7
Subject(s) - cd14 , immunology , medicine , antigen presenting cell , inflammation , population , allergy , bone marrow , allergen , monocyte , t cell , flow cytometry , immune system , environmental health
Background Allergic rhinitis (AR) is a complex inflammatory disorder where antigen presenting cells (APCs) are believed to activate allergen-specific CD4+ T cells at the site of allergen exposure. By sorting cells from the nasal mucosa in an experimental model of AR we have found, at the transcriptome level, that the total population of CD45+ HLA-DR+ cells showed signs of activation concomitant with an activated Th2 signature in purified CD4+ T cells. Bone marrow-derived APCs consists of many distinct subsets including dendritic cells (DC) and monocytes/ macrophages. The aim of this work was to study the trafficking of various APC subsets during the allergic inflammation.