Open AccessInduction of allergen‐specific blocking IgG using patch delivered recombinant Bet v 1 in guinea pigs
Author(s) -
Cabauatan Clarissa,
Campana Raffaela,
Niespodziana Katarzyna,
Reinisch Christoph,
Lundberg Urban,
Meinke Andreas,
Henning Rainer,
Neubauer Angela,
Valenta Rudolf
Publication year - 2014
Publication title -
clinical and translational allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.979
H-Index - 37
ISSN - 2045-7022
DOI - 10.1186/2045-7022-4-s2-o18
Subject(s) - medicine , allergen , recombinant dna , immunology , guinea pig , blocking (statistics) , allergy , blocking antibody , antigen , biology , biochemistry , gene , statistics , mathematics
Background Allergen-specific immunotherapy (SIT) is the only specific, disease-modifying treatment for allergy and may have long-lasting effects. It is given traditionally in the form of multiple subcutaneous injections which makes the treatment inconvenient. Furthermore, systemic allergenadministration may cause severe side effects. Therefor the development of alternative routes for SIT has been a longsought goal. The aim of this study was to investigate if epicutaneous application of recombinant birch pollen allergen Bet v 1 (i.e., patch vaccination) can induce systemic allergen-specific IgG responses with protective activity.