Open AccessBet v 1 and homologous food allergens are similarly processed by antigen‐presenting cells but differ in T cell reactivity
Author(s) -
Kitzmueller Claudia,
Zulehner Nora,
Roulias Anargyros,
Briza Peter,
Ferreira Fatima,
Bohle Barbara
Publication year - 2014
Publication title -
clinical and translational allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.979
H-Index - 37
ISSN - 2045-7022
DOI - 10.1186/2045-7022-4-s2-o12
Subject(s) - allergen , food allergy , medicine , antigen , pollen , immunology , allergy , microbiology and biotechnology , biology , botany
Background Various plant foods, e.g. apple and celery, express proteins that are homologues of the major birch-pollen allergen Bet v 1, e.g Mal d 1 and Api g 1. The proteins have 63% and 72% sequence similarity with Bet v 1 and share with it a common 3-dimensional structure. Despite this great molecular similarity, Bet v 1 is the only one among its homologues with the ability to sensitise atopic individuals. The aim of this study was to assess whether differences in the uptake and processing by antigen-presenting cells and in the presentation to T cells could be responsible for Bet v 1’s ability to sensitise.