Open AccessP41 ‐ Preexposure prophylaxis of infants’ food allergy
Author(s) -
Denisova Svetlana,
Revyakina Vera,
Sentsova Tatiana,
Belitskaya Marina,
Pavlovskaya Elena,
Vorozhko Ilia
Publication year - 2014
Publication title -
clinical and translational allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.979
H-Index - 37
ISSN - 2045-7022
DOI - 10.1186/2045-7022-4-s1-p96
Subject(s) - medicine , breastfeeding , immunoglobulin e , atopic dermatitis , allergy , food allergy , milk allergy , elimination diet , dietary therapy , immunology , allergen , lactation , antibody , pediatrics , pregnancy , biology , genetics
Methods We observed 100 “mother and child” pairs, which were divided into two groups. All children had AD, associated to cow milk protein (CMP) allergy. Lactating mothers from both groups were treated by diet therapy with the replacement of the cow milk to the New Zealand goat milk (1 group: 43 “mother and child” pairs) or non-dairy diet (2 group: 57 “mother and child” pairs). The effect of diet therapy was assessed by dynamics of clinical and immunological AD symptoms in infants after 1-3 months of treatment. Immunological effect of the therapy was assessed by the dynamics of levels of allergen-specific IgE and IgG to CMP, casein, b-lactoglobulin and goat milk protein which were measured by uncompetitive immunoenzyme assay on special test-systems from Allergopharma (Germany). The level of IFN-g, IL-2, IL-4, IL-5, IL-12, IL-13 was measured by immunoenzyme ELISA method.