Open AccessPD09 ‐ Association of the TNFα ‐308 G>A polymorphism with clinical phenotypes of asthma in Moldovan children
Author(s) -
Cirstea Olga,
Vasilos Liubov,
Cojocaru Ala,
Savoschin Dorina,
Ivaschenko Tatiana,
Aseev Mikhail,
Amoasii Dumitru
Publication year - 2014
Publication title -
clinical and translational allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.979
H-Index - 37
ISSN - 2045-7022
DOI - 10.1186/2045-7022-4-s1-p9
Subject(s) - asthma , medicine , genotype , allele , etiology , allergy , immunology , polymorphism (computer science) , gene , genetics , biology
Background Patients with asthma show a marked phenotypic variability, suggesting etiological heterogeneity and strong environmental influences. Bronchial asthma is determined by a complex interaction between genetic and environmental factors, but these mechanisms are not yet elucidated. The aim of the study was to evaluate peculiarities of the TNFa gene polymorphism (-308 G>A) incidence and its association with different clinical evolution of bronchial asthma in Moldovan children.