Open AccessP11 ‐ Immunological changes of frequently ill children with acute viral infections
Author(s) -
Ayyubova Amaliya,
Karimova Maleyka,
Magerramov NA
Publication year - 2014
Publication title -
clinical and translational allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.979
H-Index - 37
ISSN - 2045-7022
DOI - 10.1186/2045-7022-4-s1-p66
Subject(s) - medicine , immunology , proinflammatory cytokine , immune system , cytokine storm , antibody , immunity , cytokine , respiratory tract infections , disease , respiratory system , inflammation , infectious disease (medical specialty) , covid-19
Material and methods To this end, were examined 340 FIC with respiratory diseases and 125 seldom ill children for comparison. Patients were examined in the acute period of the disease and in the period clinical remission. In a study of children number of CD3-cells, CD4-cells, CD8-cells, CD19-cells, the content of serum immunoglobulins A, M, G,E, the content of cytokines IL-1beta , TNF- alpha, IL-2, IL-6, IL-8, IFN-gamma, microbiocenosis upper respiratory tract and intestinal. Results Our results show that in the acute period of the respiratory disease, reduced the level of cellular immunity (mainly, CD3-cells, CD4-cells and the index immunoregulator cells), marked imbalance of humoral immunity reduction of IgA and IgG, increase of IgM and IgE. By the marked in cytokine status increase proinflammatory cytokines IL-1beta, TNF-alpha, IL-6, IL-8 and reducing IL-2 and IFN-gamma. We found that the clinical remission of respiratory diseases in FIC is not accompanied by a normalization parameters of the immune system and cytokine status. High level of proinflammatory cytokines in the period of clinical remission, reflect ongoing inflammation, which is associated with persistence of the infection agent. Of these infections in our patients revealed chlamydia, mycoplasma, cytomegalovirus, staphylococcus aureus, candida albicans. Our FIC 67. 6% of cases in observed dysbiosis, the severity of which correlated decrease the immune system. Conclusion Saved changes in the clinical remission in frequently ill children with acute viral infections requires adequate therapy.