Open AccessPD37 ‐ Allergic disease may confer some protection against acute limphoblastic leukemia?
Author(s) -
Joacilda Conceicao Nune,
Rizzo Jose Angelo,
Medeiros Decio,
Rego Silva Almerinda,
Sarinho Emanuel
Publication year - 2014
Publication title -
clinical and translational allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.979
H-Index - 37
ISSN - 2045-7022
DOI - 10.1186/2045-7022-4-s1-p37
Subject(s) - medicine , immunoglobulin e , immunology , allergy , asthma , leukemia , disease , acute leukemia , lymphoid leukemia , population , antibody , environmental health
The results show that both total IgE serum levels and preceding history of asthma have a significant and inverse risk association with acute lymphoid leukemia. In the unadjusted model, the exposure variables with a p-value < 0.20 were: asthma, high IgE levels, concomitant allergic diseases, atopic dermatitis, allergic rhinitis and urticaria. The inverse relation to both asthma and IgE serum levels continued to be significant in the adjusted model, showing significant p-value 0.044 and OR (CI 95%) of 0.14 (0.02 – 0.95); and p-value 0.001 and OR (CI 95%) of 0.10 (0.02 – 0.41), respectively. Conclusion High levels of total IgE, especially related to asthma, appear to contribute to alterations in the immune system, which may activate Th2-mediated pathways and this fact might confer some protective role against acute lymphoid leukemia.