Open AccessPD36 ‐ Evaluation of intracellular cytokines IL‐2, IFNγ, IL‐4 and IL‐5 in children with atopic dermatitis and correlations with other immunological and epidemiological parameters
Author(s) -
Koulouri Maria,
Vrachnou Efie,
Liatsis Emmanouil,
Konstantopoulos Andreas,
Kanariou Maria
Publication year - 2014
Publication title -
clinical and translational allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.979
H-Index - 37
ISSN - 2045-7022
DOI - 10.1186/2045-7022-4-s1-p36
Subject(s) - atopic dermatitis , immunology , medicine , immunoglobulin e , cd8 , atopy , allergy , cytokine , ionomycin , cytotoxic t cell , antibody , immune system , stimulation , biology , biochemistry , in vitro
Atopic dermatitis is a chronic inflammatory disorder of the skin, charachterised by a TH2 skewed cytokine profile, usually elevated total serum IgE and can be co coexpressed with other atopic clinical manifestations. The atopic skin is prone to bacterial colonization and that has an effect on immunological parameters. Atopic Dermatitis has been correlated with IgG hypoglobulinaemia, low serum IgA and downregulation of the CD8 lymphocytes in peripheral blood.