Open AccessPD33 ‐ Drug Reaction and Eosinophilia with Systemic Symptoms (DRESS): a 10‐year review in a pediatric population
Author(s) -
Wong Sharon,
Koh Mark
Publication year - 2014
Publication title -
clinical and translational allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.979
H-Index - 37
ISSN - 2045-7022
DOI - 10.1186/2045-7022-4-s1-p33
Subject(s) - medicine , sulfasalazine , prednisolone , dermatology , rash , adverse drug reaction , constitutional symptoms , eosinophilia , pediatrics , drug , disease , psychiatry , ulcerative colitis
Results 7 patients with DRESS were identified. Patients ranged from 8 to 16 years old at the time of presentation. Inciting drugs were: Bactrim (3 cases), augmentin (1), carbamazepine (1), phenobarbitone (1), sulfasalazine (1), traditional chinese medication (1). Symptom onset ranged from 10 days to 6 weeks from the start of the inciting drug. All patients had high fever and generalized pruritic exanthematous rash. Two patients also had desquamative rashes, and one patient had purpuric papules. 4 patients had facial oedema, 4 patients had oral mucositis. Most patients had lymphadenopathy and hepatomegaly. 6 patients had significant eosinophilia, 5 had atypical lymphocytosis, and two had leucopenia. All patients had transaminitis, most at least 10x normal. Peak ALT was 1172IU/L in one patient. None suffered liver failure. One patient developed drowsiness and persistent rotatory nystagmus. Another patient had myositis. 3 patients were tested for HHV6; only one was positive. None had acute EBV infection or reactivation. All patients were treated with systemic corticosteroids. Doses ranged from 0.3mg/kg/day to 1.6mg/kg/day prednisolone equivalent. Most patients were weaned off steroids by 2 months. 5 patients had worsening symptoms despite oral steroids, with 2 patients requiring readmission. There were no fatalities. One patient developed TRAb+ hyperthyroidism 6 months later.