Open AccessPD24 ‐ Oral food challenges to peanut in the pediatric population at the Allergy Department of the University Hospital of Montpellier, France
Author(s) -
Leoni Maria Chiara,
Demoly Marie Pascale,
Chiriac Anca Mirela,
Marseglia Gian Luigi,
Demoly Pascal
Publication year - 2014
Publication title -
clinical and translational allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.979
H-Index - 37
ISSN - 2045-7022
DOI - 10.1186/2045-7022-4-s1-p24
Subject(s) - medicine , oral food challenge , peanut allergy , atopic dermatitis , asthma , allergy , population , egg allergy , pediatrics , food allergy , context (archaeology) , ingestion , immunoglobulin e , dermatology , immunology , environmental health , antibody , paleontology , biology
69 OFC to peanut were positive in 59 (38 male and 21 female) patients, aged 3-16 years (mean age, 7.56 years). 129 OFC turned out negative over the same period of time. All the patients were atopic. The most common allergens were: grass mix (44.1%), cat and dog dander (42.6%), house dust mites (38.2%), molds (29.4%) and cypress pollen (20.5%). 24 (35.2%) patients had allergic rhinitis and 45 (66.2%) had asthma (n=26 GINA 1, n=18 GINA 2, n=1 GINA 3). 29 (42.6% ) patients suffered from atopic eczema. 26 patients (41%) had no history of previous ingestion of peanuts and the avoidance regimen had been recommended either because of positive IgE and/or skin tests (in the context of atopic disease in early life) or because of reactions to cross-reactive tree nuts. 32 OFC were conducted in this population, eliciting 20 grade I reactions (62.5%), 11 (34.4%) grade II reactions and one anaphylactic shock. In the other patient group, with a clinical history of reaction to peanut itself, 29 patients (49.2%) had a history of a grade I reaction and 4 (6.7%) described grade II reactions. The 37 OFC performed in these patients were followed either by grade I or II reactions, namely the reaction was just as severe in 21 (56.7%), more severe in 13 (35.1%) and less severe in 3 patients (8.1%). The lowest eliciting dose, in terms of protein content, was 25 mg. Conclusion OFC provides data regarding the allergic status and the eliciting dose in patients with a suspicion of peanut allergy. Caution is mandatory, since reactions following OFC may be more severe than the index reaction, despite the slow progression of doses.