Open AccessPD22 ‐ Examination about eosinophilia, cytokine and gastrointestinal allergy in the preterm infant
Author(s) -
Tomomi Ogawa,
Noriko Fukuda,
Sawaki Junko,
Misaki Maiko,
Kyoko Minagawa
Publication year - 2014
Publication title -
clinical and translational allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.979
H-Index - 37
ISSN - 2045-7022
DOI - 10.1186/2045-7022-4-s1-p22
Subject(s) - medicine , eosinophilia , eosinophil , abdominal distension , gestational age , allergy , pediatrics , birth weight , neonatal intensive care unit , low birth weight , gastroenterology , immunology , asthma , pregnancy , biology , genetics
Purpose Several studies have shown the relationship between eosinophilia and gastrointestinal allergy in preterm infants; however, its mechanism has not yet been established. Interleukin (IL)-5 was shown to be involved in allergic inflammation by promoting eosinophil differentiation and activation and inducing basophil production. In this study, we examined the changes in eosinophil and basophil counts and the association with cytokines in low birthweight infants showing a predominant symptom of abdominal distension with no serious symptoms such as blood in the stool and anaphylaxis. These infants were admitted to the neonatal intensive care unit (NICU) in our hospital for 1 week or more after birth.