Open AccessP86 ‐ Magnesium sulphate in the management of severe asthma and atelectasis
Author(s) -
Sinniah Davendralingam
Publication year - 2014
Publication title -
clinical and translational allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.979
H-Index - 37
ISSN - 2045-7022
DOI - 10.1186/2045-7022-4-s1-p141
Subject(s) - medicine , salbutamol , ipratropium bromide , asthma , anesthesia , atelectasis , prednisolone , aminophylline , bolus (digestion) , bronchodilation , bronchodilator , gastroenterology , lung
Magnesium sulphate (MS), causes bronchodilation by inhibiting bronchial smooth muscle contraction, interferes with parasympathetic stimulation, and prevents acetylcholine release to axon terminals [1]. It reduces inflammation by inhibiting mast cell degranulation and reduces thromboxane, histamine and leukotrienes [2]. Some pediatric studies suggest that MS, b-2-agonists and steroids are beneficial in acute moderate/severe asthma by reducing hospitalization and absolute risk [3].