Open AccessP80 ‐ An evaluation of the efficacy and safety of a dust mite sublingual immunotherapy in allergic asthmatic children: a retrospective clinical data analysis over a three‐year period
Author(s) -
Arafa Emad,
Roberts Graham
Publication year - 2014
Publication title -
clinical and translational allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.979
H-Index - 37
ISSN - 2045-7022
DOI - 10.1186/2045-7022-4-s1-p135
Subject(s) - formoterol , budesonide , medicine , slit , combination therapy , mite , sublingual immunotherapy , house dust mite , asthma , allergy , pediatrics , immunology , allergen , botany , biology , genetics
Results The results of this study showed that SLIT group has a highly statistically significant reduction in the use of daily doses of the combination treatment (budesonide / formoterol) (p<0.0001), in comparison to control group (p=0.397). In addition, in the SLIT group there were 97% of the patients totally stopped both control and reliever medications in the final six months and only continued with SLIT. Moreover, there were more improvements in FVC and FEV1 in SLIT compared to control group. Additionally, these results revealed that SLIT significantly reduced the clinical outcome scores. There were no systematic (anaphylaxis) side effects reported with SLIT. Conclusions The results of this study suggest that SLIT has a significant role in controlling AA due to dust mite in children. Besides, the results suggest that SLIT is a safe medication for children with AA. Caution must be applied when using the results of this study in practice due to the retrospective design of this study, which means that the findings may not be transferable to routine clinical practice.