Open AccessP51 ‐ ADRB2 gene polymorphisms of the asthma pediatric patients in Russia's Perm region
Author(s) -
Furman Evgenii,
Ponomareva Mariya,
Pechenkin Yurii,
Koryukina Irina
Publication year - 2014
Publication title -
clinical and translational allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.979
H-Index - 37
ISSN - 2045-7022
DOI - 10.1186/2045-7022-4-s1-p106
Subject(s) - asthma , medicine , allergy , gene mutation , gene , mutation , immunology , bronchodilator , respiratory system , genetics , biology
B2 adrenergic receptor (ADRB2) gene variation could explain differences in bronchodilator response among patients with asthma or identify a subgroup of patients with reduced response. The aim of our research was identified polymorphisms in the ADRB2 gene in Russian asthma pediatric patients (in Perm region). 44 children from 3 to 18 years of age with bronchial asthma were examined. Mild asthma was in 95,5% , moderate asthma – in 4,5%. Gly16Arg and Gln27Glu mutations of ADRB2 gene were identified by PCR technique.