Open AccessP47 ‐ Does vitamin D status in childhood modify risk for asthma development by altering susceptibility to severe respiratory infection and allergic sensitisation?
Author(s) -
Hollams Elysia,
Zhang Guicheng,
Holt Barbara,
Kusel Merci,
Sly Peter,
Holt Patrick,
Hart Prue
Publication year - 2014
Publication title -
clinical and translational allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.979
H-Index - 37
ISSN - 2045-7022
DOI - 10.1186/2045-7022-4-s1-p102
Subject(s) - medicine , asthma , vitamin d and neurology , cohort , vitamin , allergy , cohort study , respiratory infection , immunology , vitamin d deficiency , immune system , pediatrics , respiratory system
Vitamin D has entered the spotlight in the search for preventive treatments against asthma and allergic disease due to its immune-modulating functions, shown in experimental models to include promotion of immune tolerance and boosting protection against infection. Vitamin D inadequacy is common, but disparate findings from cohort studies have had a polarising effect on the scientific community regarding the wisdom of advocating vitamin D supplementation for protection against asthma and allergic disorders. We have previously found that in the high-risk Western Australian CAS cohort (selected due to positive parental atopic history), the combination of multiple severe lower respiratory infections and sensitisation to inhaled allergens by age 2 profoundly increased risk of asthma development by age 5. Aims To determine whether vitamin D levels between birth and age 10 years in the CAS cohort are related to frequency of severe respiratory infections in early childhood, allergic sensitisation, and development of asthma by age 5o r 10 years. Methods