Open AccessO21 ‐ The role of DNA damage and repair in allergic airway inflammation
Author(s) -
Chan Tze Khee,
Loh Xin Yi,
Tan Daniel WS,
Engelward Bevin P,
Wong Fred WS
Publication year - 2014
Publication title -
clinical and translational allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.979
H-Index - 37
ISSN - 2045-7022
DOI - 10.1186/2045-7022-4-s1-o21
Subject(s) - dna damage , dna repair , immunology , inflammation , dna , apoptosis , medicine , cancer research , biology , genetics
Extensive DNA damage and inefficient DNA repair might be responsible for some of the pathogenic features in patients suffering from asthma. To determine whether DNA adducts can be used as a “dosimeter” for asthma disease severity, we measured the DNA adducts level in lung of mouse with house dust mite (HDM)-induced allergic airway inflammation, as the disease progresses. Apoptosis of airway epithelial cells is one of the most critical pathophysiological factors in the development of chronic asthma. As repairing of DNA lesions is important in preventing apoptosis, we propose that DNA repair plays an important pathophysiologic role in regulating lung epithelial cell DNA damage response.