Open AccessO20 ‐ Human rhinovirus replication‐dependent induction of micro‐RNAs in human bronchial epithelial cells
Author(s) -
Megremis Spyridon,
Taka Styliani,
Oulas Anastasis,
Kotoulas Georgios,
Iliopoulos Ioannis,
Papadopoulos Nikolaos G
Publication year - 2014
Publication title -
clinical and translational allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.979
H-Index - 37
ISSN - 2045-7022
DOI - 10.1186/2045-7022-4-s1-o20
Subject(s) - microrna , rhinovirus , mirbase , rna interference , biology , small interfering rna , rna , dicer , gene , microbiology and biotechnology , computational biology , genetics , virus
Background Micro-RNAs (miRNAs) are a class of small non-coding RNA molecules that function though post transcriptional regulation of gene expression by a process termed RNA interference (RNAi). RNAi–mediated targeting of viral RNAs is recognized as an antiviral defense mechanism. The epigenetic effect of miRNAs can either be direct, by interfering with virus genome, or indirect, through downregulation of type I IFN genes. The aim of this study is to identify HRV-A1B specific miRNAs in human broncheal cell line.