Open AccessO19 ‐ Changes in the balance between myeloid (mDC) and plasmacytoid (pDC) cell numbers in peripheral blood during childhood
Author(s) -
Maggina Paraskevi,
Papaevangelou Vassiliki,
Tsolia Maria,
Papadopoulos Nikolaos G
Publication year - 2014
Publication title -
clinical and translational allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.979
H-Index - 37
ISSN - 2045-7022
DOI - 10.1186/2045-7022-4-s1-o19
Subject(s) - medicine , immunology , myeloid , interleukin 3 receptor , cd14 , cd19 , peripheral blood mononuclear cell , flow cytometry , antigen , acquired immune system , lymphocyte , immunophenotyping , biology , biochemistry , in vitro
Background Dendritic cells (DCs) are the most potent antigenpresenting cells, having an important role in linking innate and adaptive immunity. DCs are also critical mediators of immune tolerance and anergy, depending on the type of antigen they encounter. Peripheral blood DCs represent only the 0.1–1% of mononuclear cells and, based on their lineage origins, they can be divided into two major subsets, plasmacytoid DCs (pDCs) and myeloid DCs (mDCs). Although, the total number of all blood circulating lymphocyte subpopulations in children declines with age, previous studies performed on age-related DC changes have shown controversial results [1-4].