Open AccessSelected acute phase protein in the diagnosis of late allergic response and the development of tolerance in food allergy
Author(s) -
Springer EM,
Sobieska M
Publication year - 2013
Publication title -
clinical and translational allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.979
H-Index - 37
ISSN - 2045-7022
DOI - 10.1186/2045-7022-3-s3-p95
Subject(s) - medicine , allergy , food allergy , food protein , allergic response , immunology , immunoglobulin e , food science , chemistry , antibody
in relation to T, IC, HC(p<0.001) and IR (p<0.01) groups. Diagnostic values of these estimations for prediction a late allergic reaction reached likelihood ratio (LR) 5.0-14.3, with high sensitivity (80-100%), specificity (67100%), predictive value positive (89-100%) and negative (86-100%). Furthermore high percentage of W4 glycoform seen in the group T had a high diagnostic value for differentiation with the LaR and HC groups. After food challenge significant changes in ACT level and its glycosylation profile were seen only in children not reacting to food: T, HC and IC (LR 3-6,4). Lack of these changes in sample 1 and 2 marks out mainly the IR group. Conclusion