Open AccessDesign of dendrimeric structures to treat allergic disorders
Author(s) -
Blazquez AB,
Aranda A,
Mascaraque A,
Torres MJ,
Mayorga C,
Rojo J,
Blanca M
Publication year - 2013
Publication title -
clinical and translational allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.979
H-Index - 37
ISSN - 2045-7022
DOI - 10.1186/2045-7022-3-s3-p81
Subject(s) - medicine , allergy , dermatology , intensive care medicine , immunology
Methods C56BL/6 mice were sensitized by intranasal administration of olive extract+cholera toxin B, for 6 weeks. Then, mice received immunotherapy (IT) treatment by subcutaneous (sc) injection of dendrimer-Ole1±50 mg of CpG, for 8 weeks. Seven days after the IT, mice were challenged with 100 mg of olive extract (ip). Severity of anaphylaxis was measured by drop in body temperature and the humoral response by ELISA.