Open AccessGad c 1 efficiency in the diagnosis of fish allergy in children
Author(s) -
Domínguez O,
Carrillo P,
Giner M,
Piquer M,
Alvaro M,
JimenezFeijoo R,
Lozano J,
Pascal M,
Plaza A
Publication year - 2013
Publication title -
clinical and translational allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.979
H-Index - 37
ISSN - 2045-7022
DOI - 10.1186/2045-7022-3-s3-p54
Subject(s) - parvalbumin , fish <actinopterygii> , medicine , allergy , culprit , gold standard (test) , allergen , immunoglobulin e , immunology , psychiatry , biology , fishery , genetics , antibody , myocardial infarction
Background Fish is one of the main culprit foods in childhood allergy [prevalence below 5 years 30% and then 9.8%, Spain]. IgE-mediated fish allergy diagnosis (FAD) is based on specific IgE (sIgE) detection to fish whole extracts and parvalbumin, considered to be major allergen, despite oral challenge (OC) is still the gold standard. Parvalbumin is an important panallergen. Cod parvalbumin (Gad c 1) is used for FAD in general; however its efficiency in FAD to species other than cod has not been reported. We sought to evaluate Gad c1 efficiency in FAD.