Open AccessT cell response and cytokines production after allergen stimulation in children allergic to cow’s milk protein
Author(s) -
Angelini F,
Pacciani V,
Corrente S,
Monteferrario E,
Romiti ML,
Silenzi R,
Moschese V,
Chini L
Publication year - 2013
Publication title -
clinical and translational allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.979
H-Index - 37
ISSN - 2045-7022
DOI - 10.1186/2045-7022-3-s3-p47
Subject(s) - medicine , cow's milk allergy , allergen , stimulation , allergic response , immunology , allergy , milk protein , cow milk , food science , immunoglobulin e , food allergy , antibody , biology
Background Cow’s milk protein (CMP) allergy (CMPA) affects 2-6% of children. The most important allergens are a-casein (ACA), a-lactoalbumin (ALA) and b-lactoglobulin (BLG). BLG, absent in human milk, is considered to be the major allergen of CMP. Little is known about T cells response and cytokines profile in relation to CMPA and tolerance acquisition. Our aim was to characterize T cells response and cytokines production to CMP in children with CMPA and in children who outgrew CMPA.