Open AccessNKG2D‐dependent interaction between intestinal epithelial cells and intraepithelial lymphocytes influences food allergic sensitization
Author(s) -
BolSchoenmakers M,
Rezende M Marcondes,
Kruijssen L,
Lanier LL,
Boon L,
Pieters RH,
Smit JJ
Publication year - 2013
Publication title -
clinical and translational allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.979
H-Index - 37
ISSN - 2045-7022
DOI - 10.1186/2045-7022-3-s3-p46
Subject(s) - sensitization , immunology , intraepithelial lymphocyte , medicine , nkg2d , allergy , immune system , allergic response , antibody , immunoglobulin e , biology , cytotoxic t cell , in vitro , biochemistry
Background Failure in oral tolerance induction causes allergic sensitization, but the mechanism behind this is still not fully understood. Previously, we found that the number of intraepithelial lymphocytes (IEL, including gammadelta T cells) was decreased during allergic sensitization. In addition, modulation of gammadelta T cells by a specific antibody resulted in enhanced allergic sensitization in a mouse model of peanut allergy. We hypothesized that the response of IEL to epithelial cell (IEC) perturbations due to microbial and non-microbial exposure determines the outcome of the adaptive immune response. The present study aims to investigate the involvement of Natural Killer Group 2 Member D (NKG2D) on IEL and NK cells in allergic sensitization.