Open AccessAhR pathway activation prevents food allergy in mice partly by preserving CD25‐positive Tregs in the thymus
Author(s) -
Pieters R,
Schulz V,
BolSchoenmakers M,
Smit J
Publication year - 2013
Publication title -
clinical and translational allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.979
H-Index - 37
ISSN - 2045-7022
DOI - 10.1186/2045-7022-3-s3-p43
Subject(s) - aryl hydrocarbon receptor , food allergy , medicine , allergy , immunology , il 2 receptor , regulatory t cell , gene , immune system , t cell , biology , transcription factor , genetics
Background Food allergy is an increasing health problem. We and others have shown that the intensity of food allergic reactions can be regulated by regulatory T (Treg) cells. In addition, others have shown that activation of the aryl hydrocarbon receptor (AhR) is able to induce Treg cells. Here, we investigated whether activation of the AhR could suppress food allergic responses through the induction of Treg cells in a mouse peanut allergy model.