From pollinosis to digestive allergy

Pollinosis is de ned as the appearance of respiratory symptoms (rhinoconjunctivitis and/or asthma) as a result of the inhalati on of pollen to which the individual is sensitized. Pollen allergy becomes all the more relevant on taking into account that it may be responsible for the development of plant food allergy, or may even constitute the direct cause of esophageal, gastric and/or intestinal in ammation in the context of a digestive allergic process. Pollen can act as a source of allergens that induce primary sensitization in the h ost as a result of inhalation, with secondary allergy to plant foods containing shared allergens via a cross-reactivity mechanism. The observed pattern of plant food allergy depends on the dietary habits of the population in a given geographical setting, and on the pollination found in that setting. Pollinosis may account for the greater or lesser prevalence of allergy to certain plant foods, and for the severity of the associated reactions. Beyond the digestive tract in ammation that may result from allergy to a given food, pollinosis is also intrinsical ly able to generate a clinically relevant or irrelevant Th2-mediated in ammatory response at digestive level, and may even give rise to eosinophil ic esophagitis. Inter-relation with the airway may also extend to the digestive tract as a consequence of the systemic response that characteri zes allergic disease.Key words: Food allergy, digestive allergy, allergic asthma, eosinophilic esophagitis, pollen, pollinosis, allergic rhinoconjunctivitis.