Open AccessPrevalence and clinical relevance of low levels of Pru p 3 specific IgE in patients with peach sensitization
Author(s) -
Pascal M,
Mensa A,
SánchezLópez J,
Milà J,
Millan L,
Juan M,
Valero A,
Vilella R,
Picado C,
Yagüe J,
Bartra J
Publication year - 2013
Publication title -
clinical and translational allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.979
H-Index - 37
ISSN - 2045-7022
DOI - 10.1186/2045-7022-3-s3-p109
Subject(s) - sensitization , medicine , plant lipid transfer proteins , immunoglobulin e , allergy , clinical significance , immunology , allergen , antibody , biochemistry , chemistry , gene
Background The peach Lipid Transfer Protein (LTP), Pru p 3, is considered to be a major allergen in peach allergy, but sensitization to it is almost always present in LTP-syndrome. Thus, detection of Pru p 3 specific IgE (sIgE) is frequent in routine peach and/or LTP allergy diagnosis. ImmunoCAP is one of the most frequent immunoassays for specific IgE detection, with a 0.1kU/L detection limit, although 0.35kU/L has traditionally been adopted as the positivity cutoff. The aim was to analyze the prevalence and clinical relevance of low levels of Pru p 3 sIgE in a cohort of patients diagnosed of peach sensitization.