Open AccessB cell activating factor (BAFF) and platelet activating factor (PAF) could both be markers of non‐IgE‐mediated reactions
Author(s) -
Piuri G,
Soriano J,
Speciani MC,
Speciani AF
Publication year - 2013
Publication title -
clinical and translational allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.979
H-Index - 37
ISSN - 2045-7022
DOI - 10.1186/2045-7022-3-s3-o5
Subject(s) - b cell activating factor , immunoglobulin e , immunology , platelet activating factor , medicine , histamine , tumor necrosis factor alpha , anaphylaxis , allergy , allergic inflammation , mast cell , antibody , b cell
Background B cell activating factor (BAFF) is a member of the tumor necrosis factor superfamily and an important regulator of peripheral B cell survival, maturation and immunoglobulin class-switch recombination. Many studies suggest that BAFF might be a new mediating mechanism in foodrelated inflammation. Higher levels in non-atopic compared with atopic patients, and no correlation between BAFF and IgE, suggest that BAFF might be particularly involved in non-IgE-mediated reactions [1]. According to Finkelman there are 2 pathways of systemic anaphylaxis: antigens can cause systemic anaphylaxis in mice through the classic pathway by cross-linking IgE bound to mast cell FceRI, stimulating histamine and PAF release, or the alternative pathway by forming complexes with IgG that cross-link macrophage FcgRIII, stimulating only PAF release [2]. The aim of this study is to evaluate the correlation between BAFF and PAF in non-atopic subjects.