Open AccessSafety and predictors of adverse events during oral immunotherapy with raw egg white
Author(s) -
VazquezOrtiz M,
Alvaro M,
Dominguez O,
JimenezFeijoo R,
Giner MT,
MartinMateos MA,
Plaza AM
Publication year - 2013
Publication title -
clinical and translational allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.979
H-Index - 37
ISSN - 2045-7022
DOI - 10.1186/2045-7022-3-s3-o26
Subject(s) - oral immunotherapy , medicine , white (mutation) , adverse effect , egg white , immunotherapy , allergy , family medicine , immunology , food science , cancer , genetics , biology , gene
Methods Prospective longitudinal epidemiological intervention study. Egg-allergic children aged 5–18 underwent a Spanish-approved egg-OIT protocol without premedication. Clinical data, skin prick test (SPT) and specific IgE (sIgE) at baseline and 9 months after OIT were registered. All dose-related reactions, treatments needed and cofactors involved were recorded. Through survival analysis, we studied the cumulative probability of reactions resolution over time and clinical/immunological risk factors of reactions persistence.