Open AccessImmunoglobulin E and G4 epitopes of the major allergen of birch pollen Bet v 1 share residues critical for antibody binding
Author(s) -
Groh N,
Subbarayal B,
Vogel L,
Möbs C,
Jong NW,
Pfützner W,
Wijk RG,
Lidholm J,
Meisel L,
Randow S,
Holzhauser T,
Bohle B,
Vieths S,
Schiller D
Publication year - 2013
Publication title -
clinical and translational allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.979
H-Index - 37
ISSN - 2045-7022
DOI - 10.1186/2045-7022-3-s3-o15
Subject(s) - immunoglobulin e , epitope , antibody , immunology , medicine , allergen , pollen , blocking antibody , allergy , immunotherapy , biology , botany , immune system
Background Millions of patients with allergy to birch pollen develop clinically cross-reactive IgE against Bet v 1-like proteins in plant foods. Specific immunotherapy (SIT) with birch pollen extracts induces the biosynthesis of Bet v 1-specific immunoglobulin (Ig)G4. IgG4 is believed to act as a blocking antibody preventing IgE binding to Bet v 1, thus alleviating allergic symptoms. Only little information on the location and relationship of IgE and IgG4 binding sites of Bet v 1 is available. In this study we seek to identify epitopes of IgE and IgG4 antibodies on Bet v 1.