Open AccessDry extract BNO 1011 inhibits human influenza a replication and neuraminidase activity in oseltamivir‐resistant and ‐sensitive viral strains
Author(s) -
Seifert Stephanie,
Wosikowski Katja,
Haunschild Jutta
Publication year - 2013
Publication title -
clinical and translational allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.979
H-Index - 37
ISSN - 2045-7022
DOI - 10.1186/2045-7022-3-s2-p20
Subject(s) - neuraminidase , oseltamivir , virology , microbiology and biotechnology , neuraminidase inhibitor , virus , viral replication , influenza a virus , medicine , in vitro , infectivity , influenza a virus subtype h5n1 , biology , covid-19 , biochemistry , disease , infectious disease (medical specialty)
Background Virus infection is the main triggering event for the development of acute rhinosinusitis and human influenza A virus ranks among the most frequent viral causes of infection. Influenza neuraminidase, a key enzyme in viral replication, spread, and pathogenesis, is the primary target in prevention and treatment of influenza infection. Sinupret, a herbal medicinal product composed of Gentianae radix, Primulae flos, Sambuci flos, Rumicis herba, and Verbenae herba, is frequently used for the treatment of acute rhinosinusitis.