Open AccessApoptosis factors caspases and p53 and their impact in chronic rhinosinusitis with nasal polyposis
Author(s) -
Valera Fabiana,
Küpper Daniel S,
Malinsky Rafael,
Milanezi Cristiane,
Silva João S,
Tamashiro Edwin,
AnselmoLima Wilma T
Publication year - 2013
Publication title -
clinical and translational allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.979
H-Index - 37
ISSN - 2045-7022
DOI - 10.1186/2045-7022-3-s2-o20
Subject(s) - nasal polyps , apoptosis , medicine , caspase , pathogenesis , immunology , chronic rhinosinusitis , disease , gene expression , programmed cell death , cancer research , gene , pathology , biology , genetics
Conclusion The reduced expression of these apoptosis factors in CRSwNP could be related to higher proliferation and perpetuation of inflammatory cells hindering the control of the disease. A better understanding of the possible influence of apoptosis factors on CRSwNP could be a rationale for future therapies. Author details School of Medicine of Ribeirao Preto University of Sao Paulo, Ribeirao Preto, Brazil. School of Medicine of Ribeirao Preto University of Sao Paulo, ENT Division, Ribeirao Preto, Brazil. School of Medicine of Ribeirao Preto University of Sao Paulo, Biochemistry Department, Ribeirao Preto, Brazil.