Open AccessMatrix metalloproteinases, tissue inhibitor of metalloproteinase and transforming growth factor A1 in the remodeling of chronic rhinosinusitis in North China
Author(s) -
Wang XiangDong,
Wang ChengShuo,
Bo MingYu,
Wang Hong,
Li Ying,
Fan ErZhong,
Zhang Nan,
Bachert Claus,
Zhang Luo
Publication year - 2013
Publication title -
clinical and translational allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.979
H-Index - 37
ISSN - 2045-7022
DOI - 10.1186/2045-7022-3-s2-o10
Subject(s) - nasal polyps , matrix metalloproteinase , tissue remodeling , tissue inhibitor of metalloproteinase , medicine , timp1 , chronic rhinosinusitis , pathology , immunology , inflammation , biology , gene expression , biochemistry , gene
Results MMP-8,9 were the highest among all above MMPs. MMP-8 of NP tissue was much higher than that of CRS and control tissue (P<0.001). MMP-9 of NP tissue was also significantly higher than that of CRSsNP and control tissue (P<0.05). MMP-7 of NP tissue and CRSsNP were much higher than that of control tissue (P<0.001). MMP2 of CRSsNP tissue was much higher than that of NP and control tissue (P<0.001). TIMP-1,2 were the highest among all the four TIMPs. TIMP-1 of CRSsNP tissue was much higher than that of NP and control tissue (P<0.001 and P<0.05 respectively). TIMP-2 of NP and CRSsNP tissue were much higher than that of control tissue (P<0.01). TIMP-3 of CRSsNP tissue was much higher than that of NP and control tissue (P<0.01 and P<0.05 respectively). There were no significantly difference of TGF-¦Â1 among the three groups.