Open AccessCirculating eosinophil progenitors express major trafficking related molecules and are more activated compared to mature eosinophils in patients with asthma
Author(s) -
Lu You,
Malmhäll Carina,
Sjöstrand Margareta,
Rådinger Madeleine,
Lundbäck Bo,
Lötvall Jan,
Bossios Apostolos
Publication year - 2013
Publication title -
clinical and translational allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.979
H-Index - 37
ISSN - 2045-7022
DOI - 10.1186/2045-7022-3-s1-p7
Subject(s) - eosinophil , medicine , immunology , progenitor cell , eotaxin , eosinophil granule proteins , eosinophil cationic protein , asthma , stem cell , biology , microbiology and biotechnology
Background Eosinophilic inflammation represents a hallmark for allergic asthma. Eosinophils differentiate in the bone marrow from CD34+ cells and are released into the blood and traffic to the lung tissue. To date, the majority of studies originate from animal models or from humans after allergen exposure. Thus, it is unclear if mature eosinophils and eosinophil progenitors express similar levels of trafficking related molecules. Therefore, we characterized the expression of trafficking related molecules on circulating eosinophil progenitors in patients with stable asthma.