Open AccessThe role of type 1 angiotensin 2 receptor polymorphism in asthmatic patients
Author(s) -
Cortez Margarida,
Matos Andreia,
Ferreira Joana,
Lopes Leonor,
Gil Angela,
Bicho Manuel
Publication year - 2013
Publication title -
clinical and translational allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.979
H-Index - 37
ISSN - 2045-7022
DOI - 10.1186/2045-7022-3-s1-p17
Subject(s) - asthma , medicine , statistical significance , immunology , allele , gene polymorphism , polymorphism (computer science) , genotype , restriction fragment length polymorphism , pathogenesis , gastroenterology , angiotensin ii , receptor , gene , genetics , biology
Background It is known that type 1 angiotensin II (Ang II) receptor (AGTR1) could be related with the pathogenesis of bronchial asthma. It is involved in Th polarization, through different signaling pathways modulating allergic airway inflammation, and also may participate in airway remodeling and bronchoconstriction, that could be related with AGTR1 polymorphism. The purpose of this study is to analyze the association between AGTR1 1166A/C (rs5186) gene polymorphism with asthma severity.