Open AccessACE polymorphism in asthmatic patients
Author(s) -
Cortez Margarida,
Matos Andreia,
Ferreira Joana,
Lopes Leonor,
Gil Angela,
Bicho Manuel
Publication year - 2013
Publication title -
clinical and translational allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.979
H-Index - 37
ISSN - 2045-7022
DOI - 10.1186/2045-7022-3-s1-p14
Subject(s) - medicine , bradykinin , asthma , allele , angiotensin converting enzyme , immunology , renin–angiotensin system , statistical significance , angiotensin ii , genotype , endocrinology , blood pressure , gastroenterology , genetics , biology , receptor , gene
Background The aim of the this study was to analyse if there is an association between angiotensin converting enzyme (ACE) insertion/deletion (I/D) polymorphism (287 base pairs, on chromosome 17q23, intron 16 (rs4340)) with asthma severity. ACE plays a vital role in the renin-angiotensinsystem (RAS) which regulates blood pressure by converting angiotensin I into a powerful vasoconstrictor angiotensin II, that also has an important role in airway remodeling and in inactivation of bradykinin and tachykinins. The signaling pathways, related with this polymorphism regulating the cytokine production by T cells, could induce a different Th profile modulating the immune response in asthma.