Open AccessBlinding of freeze‐dried cod – a recipe developed for the FAST project
Author(s) -
Schnoor Heidi Julius,
Witten Marianne,
Ree Ronald,
Montserrat FernandezRivas,
Poulsen Lars K
Publication year - 2011
Publication title -
clinical and translational allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.979
H-Index - 37
ISSN - 2045-7022
DOI - 10.1186/2045-7022-1-s1-p84
Subject(s) - medicine , blinding , food allergy , allergy , allergen , placebo , anaphylactic reactions , clinical trial , anaphylaxis , recipe , randomized controlled trial , dermatology , immunology , food science , alternative medicine , pathology , chemistry
Background The FAST project (Food Allergy Specific ImmunoTherapy) aims at the development of safe and effective treatment of food allergies. Classical allergen-specific immunotherapy (SIT) for treatment of food allergy using subcutaneous injections with food extracts has proven to be effective but too dangerous due to anaphylactic side-effects. FAST aims at developing a safe alternative by replacing food extracts with hypo-allergenic recombinant major allergens, the active ingredients of SIT. Fish allergy is caused by a single major allergen, parvalbumin. In phase I and II of the study randomized double-blind placebo-controlled trials will be performed. A recipe for fishblinding does not exist and is needed to determine the clinical reactivity when including patients in the trial and to assess efficacy in the Phase II trial.