Open AccessRole of double blind placebo controlled challenge test with wheat followed by exercise in patients suspected of wheat dependant exercise induced anaphylaxis (WDEIA)
Author(s) -
Van Maaren Mauritus,
De Jong Nicolette,
Mertens Frans,
Stam Henk,
Wijk Roy Gerth
Publication year - 2011
Publication title -
clinical and translational allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.979
H-Index - 37
ISSN - 2045-7022
DOI - 10.1186/2045-7022-1-s1-p73
Subject(s) - medicine , placebo , anaphylaxis , allergy , test (biology) , double blind , physical therapy , immunology , alternative medicine , pathology , paleontology , biology
Methods Patients characterized by a history of at least two anaphylactic reactions during exercise within four hours following ingestion of wheat and the presence of specific IgE to ω-5gliadin ≥.0.89 Ku/L were asked to undergo a DBPFC with wheat masked in a pancake followed by an exercise test . Patients with negative responses were asked to participate in an open challenge test thereby consuming a 2.5 fold higher amount of wheat compared to the dose ingested in the blinded test.