Open AccessThe most common cow’s milk allergenic proteins regarding to allergic symptoms
Author(s) -
Shoormasti Raheleh Shokouhi,
Pourpak Zahra,
Yazdanyar Zahra,
Lebaschi Zahra,
Teymourpour Pegah,
Barzegar Saeedeh,
Tazesh Behnaz,
Fazlollahi Mohammed Reza,
Movahedi Masoud,
Dashti Parisa,
Moin Mostafa
Publication year - 2011
Publication title -
clinical and translational allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.979
H-Index - 37
ISSN - 2045-7022
DOI - 10.1186/2045-7022-1-s1-p62
Subject(s) - medicine , immunoglobulin e , lactalbumin , anaphylaxis , casein , allergy , gastroenterology , immunology , food science , antibody , biology
Results Eighty six patients with CMA (3month to 18 yrs) were entered this study Fifty three patients were males (61.1%). Median of age was 2.5 yrs (Mean=3.98) and most of CMA patients was under 2 yrs (45.1 %). Mean of total IgE was 343.39±93.63 (SE)(0.2-5000IU/ml). The symptoms of patients was as following: (respiratory symptoms: 62.8%, Skin symptoms: 56.4%, gastrointestinal symptoms: 19.2% & Anaphylaxis: 13.6%). Totally, positive Specific IgE to cow’s milk protein, a-lactalbumin, casein, b-lactoglobulin and bovin serum albumin were 89.2%, 78.3%, 75%, 63.4%, & 45.5%, respectively. Although a-lactalbumin & casein were the most allergenic protein, mean of specific IgE concentration to blactoglobulin was highest in patients with CMA. There was a significant correlation between positive specific IgE to b-lactalbumin & anaphylaxis (P=0.05) and also between respiratory symptoms and positive specific IgE to casein (P=0.01). There was significant difference between mean of specific IgE to casein between males and females (P=0.001) that was the more frequent in males.