Open AccessAdverse reactions to food in patients with mastocytosis
Author(s) -
Pucino Valentina,
Magliacane Diomira,
Petraroli Angelica,
Triggiani Massimo
Publication year - 2011
Publication title -
clinical and translational allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.979
H-Index - 37
ISSN - 2045-7022
DOI - 10.1186/2045-7022-1-s1-p35
Subject(s) - medicine , systemic mastocytosis , dermatology , allergy , adverse effect , intensive care medicine , immunology , mast cell
Background Mastocytosis is a disease characterized by abnormal growth and accumulation of mast cells (MC) in different tissues. The disease can be classified as cutaneous (CM), when MC infiltrate is limited to the skin, and systemic mastocytosis (SM) when MC proliferate in other organs such as the bone marrow, gastrointestinal tract, lung, liver, spleen or lymph-nodes. Clinical symptoms of CM and SM are related to the release of MC-derived mediators and/or to tissue infiltration by MC. The increased number of MC in various organs, including the gastrointestinal tract, raises the question whether patients with mastocytosis may have a high frequency of adverse reaction to food (ARF).